If you regularly get treated with botox you can become immune to it.
German researchers found that one in 200 people develop antibodies to Botox after using it too often. As a result, more and more botox is needed to make the treatment effective.
Bootox Breakdown
A doctor who has been treating people with Botox for years sees that the treatment becomes less effective over time and also wears off more quickly. "It seems that their bodies are breaking down the botox faster and faster." The botox producer indicates that it is indeed possible that people become immune to the substance, but according to them it is rare.